Ferritin hogt inflammation

There is a clear need for further investigation of the role of ferritin in uncontrolled inflammatory conditions both as a biomarker and mediator of disease because its occurrence identifies patients with high mortality risk and its resolution predicts their improved survival. 1 hemokromatos ogon 2 Ferritin was initially described to accompany various acute infections, both viral and bacterial, indicating an acute response to inflammation. 3 hogt jarnvarde cancer 4 Ferritin as a trigger of inflammation. It is well known that serum ferritin is an acute-phase reactant, reflecting the degree of acute and chronic inflammation in several systemic diseases. However, emerging evidence suggests a potential causative role for ferritin in the inflammatory process. In this regard, in vitro studies showed that. 5 High ferritin, hyperferritinemia, may indicate increased iron stores, but is more commonly seen upon acute phase reactions and as a result of ferritin being released from damaged cells such as hepatocytes in liver disease [ 5 ]. 6 Ferritin is a critical protein in iron homeostasis. • Acute phase reactant has been used for long time to explain high levels of ferritin in acute inflammatory as well as acute infections. • Hyperferritinemia was later introduced to include severe autoimmune and inflammatory conditions which share in common extremely elevated ferritin. 7 ferritin gransvarden 8 Forhojt blodvarde av ferritin . 9 Dock kan s-ferritin vara hogt vid akut leverinflammation som virushepatit, autoimmun hepatit eller lakemedelsinducerad leverskada e t c. 10 hogt ferritin cancer 12